Curious about what Andarine (S4) can do for your physique and performance? This selective androgen receptor modulator (SARM) is a favourite in bodybuilding research for its ability to build lean muscle, boost strength, and carve out a defined, vascular look. Unlike steroids, it targets muscle and bone receptors, offering gains with fewer side effects. Here’s a deep dive into the science, benefits, and effects of Andarine S4, plus tips for safe use with bloodwork monitoring.
What Is Andarine S4?
Andarine (S4) is a SARM that selectively binds to androgen receptors in muscle and bone tissue. Dosed at 25-50 mg daily (split doses) for 6-8 weeks, it’s researched for lean muscle growth, strength, and fat loss. It may cause mild testosterone suppression at higher doses, potentially requiring a Post-Cycle Therapy (PCT) like Recharge 2.0.
History of Andarine S4
Developed by GTx, Inc. in the early 2000s for muscle-wasting conditions, osteoporosis, and benign prostatic hyperplasia, Andarine S4 showed promise in early trials but was discontinued in favour of Ostarine. Its ability to deliver Andarine S4 effects like muscle growth and fat loss without heavy side effects made it a bodybuilding research staple, especially for cutting and recomp phases.
The Science Behind Andarine S4 Effects
Muscle Growth
Andarine S4 binds to androgen receptors (Ki ~4 nM), activating pathways like mTOR to enhance protein synthesis. Preclinical studies report 1-2 kg lean mass gains in 8 weeks at human-equivalent doses, with human anecdotes aligning. It promotes lean, dry muscle without water retention, ideal for a sculpted physique.
Strength and Endurance
Andarine S4 effects include 10-20% strength increases in lifts, per user reports, due to improved muscle fibre recruitment. It also boosts endurance by enhancing oxygen utilisation, supporting longer, intense workouts for better performance.
Fat Loss and Definition
Andarine reduces lipoprotein lipase (LPL), an enzyme linked to fat storage, leading to 5-7% body fat reduction in 8 weeks in studies. It preserves muscle during calorie deficits, enhancing vascularity and muscle hardness for a chiseled look.
Bone and Joint Health
By binding to bone receptors, Andarine supports bone density and joint health, reducing injury risk during heavy training, as shown in rat studies.
Key Benefits of Andarine S4 Effects
- Lean Muscle: 1-2 kg lean mass gains in 6-8 weeks.
- Strength: 10-20% lift increases for power training.
- Fat Loss: 5-7% body fat reduction, enhancing definition.
- Vascularity: Promotes a dry, hard, vascular physique.
- Bone Density: Supports skeletal health, lowering injury risk.
Stacking Andarine S4 for Enhanced Results
For amplified Andarine S4 effects, stack with Cardarine in the Shred Stack. Cardarine boosts endurance and fat loss (up to 8-10% body fat reduction), while Andarine builds lean muscle, yielding 2-3 kg gains and a shredded look in 6-8 weeks.
Bloodwork Monitoring
Andarine may cause mild testosterone suppression at higher doses, so bloodwork is crucial. Test:
- Total/Free Testosterone: Monitor suppression.
- Oestradiol: Check oestrogen levels.
- Liver Enzymes (ALT, AST): Assess for strain.
- Lipid Panel: Track cholesterol, as HDL may drop.
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Maximising Andarine S4 Effects
- Nutrition: High-protein (1.6-2.2 g/kg bodyweight), slight calorie deficit for fat loss.
- Training: Heavy lifts for strength; high-volume for definition.
- Timing: Split doses (morning/evening) due to 4-6 hour half-life.
- Cycle: 6-8 weeks, with PCT if needed.
Considerations
Human data is limited; preclinical studies dominate. Side effects may include temporary vision changes (yellow tint, rare at 25 mg), mild suppression, or headaches. Bloodwork and professional guidance are essential. Andarine is not FDA-approved and may be banned in some places and sports.
Protocol
- Andarine S4: 1-2 capsules (25-50 mg) daily, split doses.
- Cycle: 6-8 weeks.
- PCT: May be needed at higher doses; use Recharge 2.0 if suppression occurs.
Disclaimer: The products discussed are for research purposes only and not for human consumption. Do your research and consult a professional before use. APH Science is not responsible for misuse.
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