Andarine S4 is a popular Selective Androgen Receptor Modulator (SARM) known for boosting lean muscle, strength, and fat loss, making it a go-to for cutting and recomp cycles. But does it require Post-Cycle Therapy (PCT) to maintain gains and hormonal health? Unlike some SARMs, Andarine S4’s impact on testosterone is dose-dependent, so PCT needs vary. This post explores why PCT may be necessary, how it works, and how to use it safely with bloodwork monitoring.
What Is Andarine S4 and Why Might It Require PCT?
Andarine S4 selectively binds to androgen receptors in muscle and bone, promoting 1–2 kg lean mass gains and 5–7% fat loss in 6–8 weeks, per research. Dosed at 25–50 mg daily (split doses due to a 4–6 hour half-life), it’s less suppressive than SARMs like RAD 140 but can still reduce testosterone, especially at higher doses or longer cycles. Suppression occurs via the hypothalamic-pituitary-gonadal axis (HPGA), lowering luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which signal testosterone production. Without PCT, low testosterone risks muscle loss, fatigue, or libido issues post-cycle.
PCT, such as Recharge 2.0, uses Clomiphene citrate and Zinc citrate to stimulate LH/FSH, restore testosterone, and manage estrogen, ensuring you keep your gains and recover fully.
When Is PCT Necessary for Andarine S4?
Testosterone Suppression
Andarine S4 causes mild suppression at 25 mg/day, with studies showing minimal testosterone drops in 6–8 weeks. At 50 mg/day or cycles >8 weeks, suppression can reach 20–30%, per anecdotal reports. PCT is often recommended for:
- Doses ≥50 mg/day
- Cycles >8 weeks
- Signs of suppression (fatigue, low libido, mood changes)
- Bloodwork showing reduced testosterone/LH/FSH
At 25 mg/day for 6–8 weeks, many users report no significant suppression, potentially skipping PCT if bloodwork confirms normal levels.
Preserving Lean Gains
Andarine’s muscle gains (1–2 kg) rely on anabolic signaling. Low testosterone post-cycle can lead to catabolism, losing 10–20% of gains without PCT. Recharge 2.0 helps maintain an anabolic state.
Hormonal Balance
Andarine may slightly elevate estrogen, though less than other SARMs. PCT prevents estrogen-related side effects (e.g., gynecomastia) by blocking receptors and supporting testosterone recovery.
Overall Health
Suppression can cause lethargy or mood dips. PCT restores energy, libido, and mental focus, minimising hormonal disruption.
Bloodwork Monitoring
Bloodwork is crucial to determine PCT necessity. Test:
- Total/Free Testosterone: Assess suppression and recovery.
- Oestradiol: Monitor estrogen levels.
- LH/FSH: Check HPGA function.
- Liver Enzymes (ALT, AST): Ensure no strain.
- Lipid Panel: Track cholesterol, as S4 may lower HDL.
Test pre-cycle, mid-cycle (3–4 weeks), and post-cycle (1–2 weeks after PCT). Use LetsGetChecked with code SARMS20 for 20% off. Bloodwork guides whether PCT is needed and tracks recovery.
How to Run a PCT After an Andarine S4 Cycle
Recharge 2.0 is designed for SARM cycles, combining Clomiphene (25 mg) and Zinc Citrate (10 mg) per tablet. Protocol:
- Duration: 4–5 weeks (shorter for mild suppression).
- Dosage: 2 tablets daily (50 mg Clomiphene, 20 mg Zinc) for 1–2 weeks, then 1 tablet daily (25 mg Clomiphene, 10 mg Zinc) for 2–3 weeks.
- Timing: Start 1–2 days after last S4 dose (short half-life).
Clomiphene stimulates LH/FSH to restart testosterone, while Zinc supports hormonal health. Consult a professional to adjust based on bloodwork.
Tips for a Successful Andarine S4 Cycle
- Nutrition: High-protein (1.6–2.2 g/kg bodyweight), slight calorie deficit for cutting or maintenance for recomp.
- Training: Volume training (8–12 reps) for definition; heavy lifts (4–6 reps) for strength.
- Cycle Length: 6–8 weeks to minimise suppression.
- Bloodwork: Use LetsGetChecked (code SARMS20) for pre-, mid-, and post-cycle checks.
- Dose Conservatively: Stick to 25 mg/day to reduce suppression risk; avoid >50 mg/day.
Considerations
Human data on Andarine S4 is limited; preclinical studies dominate. Side effects include mild suppression, temporary vision changes (yellow tint, rare at 25 mg), or headaches. Bloodwork detects issues early. PCT is typically needed at higher doses (≥50 mg/day) or longer cycles (>8 weeks), but low-dose, short cycles may not require it—bloodwork confirms. Andarine is not FDA-approved for human use, so professional guidance is essential.
Protocol
- Andarine S4: 1–2 capsules (25–50 mg) daily, split doses (morning/evening).
- Cycle: 6–8 weeks.
- PCT (if needed): Recharge 2.0, 2 tablets daily for 1–2 weeks, then 1 daily for 2–3 weeks, starting 1–2 days post-cycle.
Disclaimer: The products discussed are for research purposes only and not for human consumption. Do your research and consult a professional before use. APH Science is not responsible for misuse.
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