The Ultimate Guide To Selective Androgen Receptor Modulators (SARMs)

SARMs, or Selective Androgen Receptor Modulators, are a relatively new class of drugs that have been growing in popularity in recent years. They offer the benefits of traditional anabolic steroids such as increased muscle mass and strength, with fewer side effects.

Let's check-out an overview of what SARMs are, how they work, and some of the potential benefits and any known side effects associated with their use.

Introduction

SARM is a class of ligands aimed at androgen receptor binding and displaying tissue specific activation of androgenic signaling. The SARM has an anaerobic effect on muscle and bones and was initially developed to treat muscle and bones ailments such as osteoporosis, breast cancer and cancer. No clinical approval has yet been obtained regarding SARMs and few studies have been done about their beneficial effects.

With that said, SARMs are widely used in the fitness community for maximising gains.

Most Popular SARMS

Testolone/RAD-140

Rad 140, or Testolone, is the latest generation of SARMs. Although it has anabolic properties, it does not quite have the androgenic effect that hormones do. 

RAD 140 can:

• Improve stamina for athletes during workouts

• Reinforce bone and teeth health

• Protect against deterioration of the brain

• Be much Less harmful side-effects compared with taking testosterone or anabolic steroids

Liver Toxicity Of RAD 140 (Testolone)

In recent years, Testolone has been used to treat muscle weakness or breast cancer. Testingolone has been tested in the early phases of a new clinical program in North America by Radius Health. The results of those studies should be released in early 2019.

So far, there is still not enough research done on Testolone to accurately discuss liver toxicity, however one recent case report described significant liver damage from taking the SARM. Elevations of bilirubin, AST, ALT, and creatinine showed mixed hematopoietic liver damage. Hetology on liver showed inflammatory reactions too. All liver tests were normal within a period of one year of a patient presenting the initial diagnosis.

The benefits of testolone include increased muscle mass and strength, as well as a reduction in fat mass. It has also been shown to improve bone density and reduce the risk of fractures. Testolone is a non-estrogenic SARM, which means it does not produce the feminizing side effects often associated with estrogenic steroids.

Ligandrol/LGD-4033

LGD 4033 is a Selective Androgen Receptor Modulator (SARM) that has been shown to have a variety of benefits, including increased muscle mass and decreased fat mass. LGD 4033 binds to the androgen receptor and mimics the effects of testosterone, leading to increased protein synthesis and muscle growth. Unlike traditional anabolic steroids, LGD 4033 does not cause liver damage or other adverse side effects. In addition, LGD 4033 has been shown to be effective in treating muscle pain associated with conditions like osteoporosis and cancer.

Ligand Pharmaceuticals commenced the first clinical study using its drug. In a placebo study 76 healthy men received a placebo versus 0.1 mg / 0.4 mg / or 1.0 mg / 0.5 mg. It has been tolerated with minimal side effects.

While Ligandrol is generally considered safe for use, there are still some risks associated with their use. The most common side effects of SARMs include headache, nausea, and fatigue. Consult with a healthcare professional before taking Ligandrol, as is is not approved by the FDA for human usage.

Is Ligandrol-For Cutting Or Bulking?

LGD-4033 For Bulking Cycles

Among all selective androgen receptor modulators, LGD-4033 is the most anabolic. Consequently, it's optimal for both gaining strength and packing lean mass. Ideally, you should slightly increase your calorie consumption above maintenance levels (by 200-300 calories), making sure that the food is clean.

If you want to see results from LGD-4033, hitting the gym hard is a must, but eight to twelve weeks of consistent use will give you crazy gains.

LGD-4033 For Cutting Cycles

LGD-4033 is a great SARM for cutting cycles. You can stack it with S-4 (Andarine) to get increased muscle size and steady fat loss over eight to twelve weeks.

However, it's important to note that the success of your LGD-4033 cycle will largely depend on your diet and workout routine. Staying hydrated and getting quality sleep are also key components for a successful cutting cycle.

LGD-4033 For Recomposition Cycles

If you're unsure about using LGD-4033, Recomposition would be a great starting point. All you need to do is maintain your calorie intake and eat clean, then go all out at the gym. By doing this, you can build solid muscle while losing stubborn fat around your midsection.

You may see a temporary net weight gain at first, but don't be discouraged. After just a few weeks of using LGD-4033, you will experience an amazing transformation in your body. Plus, you'll notice increased reps and solid strength gains across all your lifts.

Ibutamoren/MK-677

Ibutamoren is an investigational drug that has not been approved by any regulatory agency for human use. The drug is currently being studied in a clinical trial for its potential to treat growth hormone deficiency. Ibutamoren is a non-peptidic agonist of the ghrelin receptor and a growth hormone secretagogue. Ibutamoren increases secretion of several hormones, including growth hormone and insulin-like growth factor 1 (IGF-1), but its exact mechanism of action is not well understood.

Ibutamoren has been shown to increase muscle mass and strength in animal studies, as well as improve bone density and reduce the risk of fractures. Ibutamoren is orally bioavailable and has a long half-life, making it convenient to use. However, because it is a relatively new drug, its long-term safety profile is not well understood.

Benefits Of Ibutamoren (MK-677)

Muscle Building:

Ibutamoren is an incredibly effective way to increase the level of lean body mass. It also works well for increasing muscle size, strength, and definition while reducing fat stores.

Minimise Muscle Waste:

Among performance-enhancing drugs, Ibutamoren is one of the most effective for reversing diet-induced weight loss and muscle wasting. What's more, Ibutamoren (MK677) has been shown to markedly improve gait speed and muscle strength in elderly patients with hip fractures while reducing falls.

Improved Sleep:

Multiple scientific studies have found that Ibutamoren significantly improves the duration and quality of Rapid Eye Movement (REM) sleep.

Tackles Muscle Mass Decline:

Ibutamoren not only improves levels of IGF-1 and growth hormone, but it does so without any harmful side effects. This makes it an ideal option for people who are naturally seeing a decline in muscle mass or have decrease GH due to aging.

Increased Bone Density:

Ibutamoren (MK677) is an excellent drug for increasing bone turnover and density.

Cognitive Enhancer and Nootropic Benefits:

People Ibutamoren because it is a nootropic; this is possible due to the fact that it acts on the ghrelin receptor. The Ghrelin receptor has enhancer properties which means that cognitive functions are improved. Learning and memory specifically are boosted by Ibutamoren (MK677) because it increases insulin-like growth factor 1 levels.

Another advantage of taking Ibutamoren (MK677) is that is helps improve sleep quality as well as duration; both deep sleep and REM states contribute to enhanced cognitive functioning.

Elevates Growth Hormone Levels:

MK-677 has been shown to improve levels of IGF-1, growth hormone, andInsulin-like growth factor binding protein 3 (IGFBP-3) in children with growth hormone deficiency. The most interesting aspect is that these elevated effects can be experienced by children without any changes in their concentrations of thyrotropin, prolactin, glucose, triiodothyronine(T3), thyroxine (T4), cortisol, or insulin.

Improving tissue regeneration and wound healing:

Ibutamoren (MK677) not only has the potential to heal old injuries and tighten saggy skin, but also mends tendons, bones, and ligaments. It's just as good for healing wounds and helping new tissue grow.

Improves shredding:

Ibutamoren (MK677) can help bodybuilders and athletes who are trying to lose weight by increasing their hunger and helping them consume more calories. Ibutamoren (MK677), which increases Ghrelin (a hunger hormone), plays an important role in regulating the use of energy (stored fat). In other words, Ibutamoren (MK677) can help them retain muscle mass even when they are on a calorie-restricted diet.

Ibutamoren MK677 For Men

The ideal way to use Ibutamoren is once in the morning and again at night, given its 24-hour half-life. However, some people who are more advanced athletes or bodybuilders do choose to use it daily at a dosage of 50-75mg (up to three times the suggested limit).

The suggested Ibutamoren cycle is 8-12 weeks for men, and again should be significantly shorter for women. During a bulking stack, many users consider 10mg of RAD-140 (Testolone) alongside the two split dosages. Again, this should be discussed prior to usage and stacking should not be attempted by those new to taking supplements. 

Ibutamoren (MK 677) can be used daily in cutting cycles at dosages of 12.5mg GW-5015216 (Cardarine), 20mg per day for 6-10 weeks,(all quantities for men). It may also be stacked with other SARMs for maximum gains, typically in a cycle of 8-12 weeks Dosage recommendations are 25 mg/day.

Be mindful that, as with other drugs, Ibutamoren (MK 677) dosage amounts should never be increased without medical supervision. Although results may take some time to become evident, hasty decisions can often lead to negative consequences later on.

Ibutamoren MK677 For Women

Women need to take a lower dosage of Ibutamoren (typically half the amount recommended for men) However, hormones and other individual factors play a big role in how each person reacts to medications, so it's never safe just to estimate!

MK 677 (Ibutamoren) should not be used by anyone who is pregnant or breastfeeding, children under the age of 21, or those hypersensitive to its active or inactive ingredients.

To ensure your safety, it is always best to speak with a medical professional before taking any medication. This Selective Androgen Receptor Modulator is no different. Ibutamoren (MK 677) may have great benefits, but it's also important to be cautious.

Ostarine/MK-2866

Ostarine is a selective androgen receptor modulator (SARM) derived from GTT in the late 1990s that is currently being investigated for its potential to treat muscle wasting and osteoporosis.

Like other SARMS, Ostarine binds to androgen receptors, which can lead to anabolic effects such as increased muscle mass and strength. Ostarine has also been shown to improve bone density and reduce the risk of fractures.

Benefits Of Ostarine

Ostarine is an excellent way to improve your gym performance and results from resistance training, strength training, and cardio sessions.

• Unmatched muscle mass and size gains

• Cycle gains will be long-lasting and easy to retain

• Cardio sessions and bodybuilding workouts can be optimised

• Stamina, vascularity, and strength gains will all be promoted

• Helps users break through training plateaus

• Quicker recovery time between workouts

• Aids in muscular healing, recuperation and recomposition.

• Increases in pump fullness and reduced post-work out soreness are other

Ostarine Dosage For Men

The ideal length of an Ostarine cycle for men is 10-14 weeks, during which they should take 15-25mg per day. This can be taken as two equal doses: one in the morning and one at night. It's best to consume Ostarine after meals and 30-40 minutes before a workout. Keep in mind that its half-life is 20-24 hours, so taking it just once a day is perfectly fine.

Ostarine should only be used for legitimate and medicinal purposes after its use has been approved by a registered medical practitioner, who will have looked over medical history and reports. Ostarine dosages should never be abused in hopes of quick results becauset this could lead to dangerous consequences--even death.

Ostarine Dosage For Women

The recommended dosage for female users of Ostarine is 5-10mg per day, to be taken after meals and 30-40 minutes before workouts. Twice daily dosages (equal morning and evening doses) are also acceptable for women using this performance booster.

It is important to note here that legit MK-2866 should not be used by breastfeeding or pregnant women. The use of Ostarine should always be done for legal and medicinal purposes and only after a registered medical practitioner has approved its use after evaluating all medical reports and history.

Cardarine

GW-501516, also known as Cardarine, is one of the most effective SARMs for eliminating pesky abdominal and visceral fat. Not only that, but it helps get rid of thigh-, butt-, and upper arm fat too. This is because Cardarine increases the rate at which stored fat gets converted into energy by the body. In other words: Cardarine helps you look leaner and lose fat quickly.

GW-501516 is widely known to be the most effective fat stripper and has been demonstrated to help fix metabolic issues in obese people with pre-diabetic metabolic syndrome. Cardarine is recommended as a potential treatment for obesity because of its unmatched ability to stimulate the loss of abdominal and visceral fat.

Here are some of Cardarine's benefits

• Significantly improves cardiovascular endurance

• Dramatically reduces recovery time between workouts

• Enables a huge increase in available training volume

• Drives astonishing gains in single workout performance levels

• Improves mood and a general sense of wellbeing rapidly

• Begins working from the very first dosage

Among the most reliable options for enhancing cardiovascular endurance and energy when reducing calories, Cardarine is a selective androgen receptor modulator. GW-501516 also notably strengthens you so that you can train more intensely for longer periods of time.

Cardarine not only allows your muscles to use oxygen more efficiently but also enhances the PPAR gene expression located in slow-twitch muscle fibres. This ultimately results in a faster recovery rate, so you can work out more frequently and with greater intensity.

Cardarine is key for gaining lean muscle mass. GW-501516, especially during a SARMs cutting cycle, helps you gain lean muscle mass by developing existing cells and stimulating the formation of new ones.

Frequently Asked SARM Questions:

Do SARMs Help Cure Breast Cancer?

Increases in androgen synthesis can increase the chance of breast cancer. Androgen can lead to virility in the females. Similar to SARMs which affect breast and skin cells and also affect breast and ovarie tissues, they also exert an affect on the breast tissue, which is expressed as AR. Thankfully, increased breast cancer survival can be related to the expression of ar expression, a protein that occurs 80% to 5% in ER-positive breast cancer versus 98% in ER-negative breast cancer. The SARMs are now able to modulate their outputs with unique advantages.

SARMS Can Prevent Muscle Wasting

Initially SARMs were used in cancer-related cases of age and cachexia as a potential alternative to TTH (228,70). In addition to preventing the development of androgenic side effect, SARMs treat muscle pain associated with a variety of chronic conditions such as heart failure, chronic obstructive pulmonary disease (COPD), HIV, end-stage renal and liver failure, chronic infections and more. Studies have shown that sarcopenia has the potential to cause mortality in cancer and sarcopenia is associated with higher rates of death.

Potential Abuse

Performer enhancer drugs such as exogenous testosterone can become an ongoing concern in athletics and result in anti-doping measures. SARM is a highly addictive and corrosive drug with high potential abuse rates and its high side repercussions. SARM products can still be ordered from online retailers, although the FDA does not approve it. Despite being offered under the name SARM, studies show a large proportion of such sites are misleadingly labeled or contain unapproved substances, with only 52% containing SARM active.

Male Contraception.

A recent report has identified SARMs as a viable option for female circumception, especially given they appear less prone to adverse effects. A recent study analysed two SARMs, C-6 and S-23 in animals by Solomon and colleagues. In animal models, S-23 has shown a potential to inhibit 'spermatogenicity' and decrease fat mass.

Conclusion

You can find a list of all the SARMs discussed above on our website here:

https://aphscience.com/collections/sarms

Disclaimer: Always discuss potential dosages with your doctor or qualified expert. SARMS are a relatively new class of performance enhancing drugs that are still in the experimental phase. The long-term effects of using SARMS are not fully known. As with any new drug, please consult a qualified medical professional before using SARMS.