Ligandrol (LGD 4033) is a powerful and popular new drug that has been shown to produce impressive muscle gains in a short period of time. It is a member of the selective androgen receptor modulators (SARMs) family and works by binding to the androgen receptors in the body. This produces anabolic effects similar to those of testosterone, without many of the negative side effects.
Ligandrol is still relatively new, so there is limited scientific research on it available. In this article, we will take a comprehensive look at Ligandrol, including its history, mechanism of action, benefits, potential side effects, and more!
About Ligandrol LGD 4033
History
Ligandrol was first developed by Ligand Pharmaceuticals in the early 2000s. It was originally designed as a treatment for muscle-wasting diseases such as cancer and osteoporosis. However, Ligandrol has since been repurposed for use by bodybuilders and athletes. This is because Ligandrol can promote dramatic increases in muscle mass and strength, with some users reporting gains of up to 10 pounds of lean muscle mass in just a few weeks!
The Science
So how does Ligandrol work? As mentioned earlier, Ligandrol binds to the androgen receptors in the body. This triggers a protein synthesis cascade that leads to muscle growth. In addition, Ligandrol inhibits myostatin, a protein that normally limits muscle growth. By inhibiting myostatin, Ligandrol allows you to build more muscle than you would otherwise be able to.
In terms of benefits, Ligandrol has been shown to:
-
Promote dramatic increases in muscle mass and strength
-
Enhance athletic performance
-
Improve recovery from exercise
-
Increase bone density
-
Reduce body fat
FAQs
What does Ligandrol do to your body?
Ligandrol helps in strengthening muscle tissues. Despite studies on this medication being used in the treatment of cancers and others causing muscle loss and wastage, it is not allowed for sportsmen and women.
What are the side effects of LGD-4033?
LGD-4033 is safe and tolerates every dose. The frequency of adverse reactions varies in varying dose groups and placebos as well. In general, headaches, pains caused by a muscle biopsy, and dry mouth are not attributed to dose relationships.
LGD4033 may also cause dry mouth.
Hair loss
Several LGD 40033 users report balding or receding hair on their scalp, as a result of anabolic steroids. The reason for this hair loss can be attributed to two different factors. Like how estrogens may indirectly increase by binding to another receptor - this also increases DHT levels in the body (increasing the natural levels in 5-alpha reducta). HT (Dishydrotestosterone) is a hormone affecting hair growth that is causing alopecia in excessively high doses. The other possibility behind LGD-related hair loss is Telogen efflux.
Testosterone Suppression
Although nonstrepatory, sarma can still reduce natural testosterone by attacking androgen receptors. It lowers LH (luteinizing hormone) and follicular stimulating hormone. The LGD 4033 SARM is the strongest SARM in the market and therefore considered to be the strongest suppressed drug. In a previous study using lignaline 1mg/day, participants' total testosterone decreased by 50%. Free testosterone also fell by 40%. After 60 days of cessative treatment endogenous testosterone returned to its normal range.
Water Retention & Gynecomastia
In theory, the LGD 4033 is unlikely to have estrogen effects because of its absence from aromatherapy, or directly stimulates estrogen receptors. Ligandrol competes with body hormones in promoting binding to androgen receptors. LGD4033 has higher affinity, meaning that the body is losing its naturally occurring testosterone and instead becomes able to attach to another receptor such as estrogen. Consequently, LGD 4033 can indirectly increase estrogen levels, causing bloating or gynecomastia.
Does LGD raise testosterone?
Despite it being known that LGD4033 can affect testosterone production, it is also known to alter hormonal signals in the body. It does this by binding to the androgen receptors in the body. This produces anabolic effects similar to those of testosterone, without many of the negative side effects. Ligandrol is still relatively new, so there is limited scientific research on it available.
How long does Ligandrol stay in your system?
Ligandrol can be detectable in your system for up to 5 weeks after your last dose. This means that you will need to take a break from using Ligandrol if you are drug tested within this time period.
Will Ligandrol show up on a drug test?
Ligandrol is not currently on most drug testing panels. However, this could change in the future as Ligandrol becomes more popular. If you are subject to drug testing, it is always best to check with your testing authority to see if Ligandrol will be tested for.
How much Ligandrol should I take?
The recommended dosage of Ligandrol is 3-5 mg per day. However, some users may need to take up to 10 mg per day to see results. It is always best to start at a lower dose and increase as needed. Ligandrol is a very powerful SARM, so it is best to err on the side of caution when starting out.
When should I take Ligandrol?
Ligandrol can be taken any time of day. However, some users find that taking Ligandrol in the morning or before their workout provides the best results.
How long does it take for Ligandrol to work?
Some users report seeing results from Ligandrol within just a few days. However, it typically takes 2-4 weeks for full results to be seen.
Is Ligandrol legal?
Ligandrol is not currently approved for human use. However, it is legal to purchase and use Ligandrol for research purposes.
Is Ligandrol safe?
Ligandrol is generally considered safe when used as directed. However, like all supplements, there is always the potential for side effects. If you experience any adverse reactions while taking Ligandrol, stop taking it immediately and consult a doctor.
Potential Side Effects
As for potential side effects, Ligandrol is generally well tolerated by users. The most common side effect is mild nausea, which usually goes away on its own. In rare cases, users may experience more serious side effects such as liver damage or high blood pressure. However, these side effects are typically only seen in people who abuse Ligandrol or take it in large doses.
Overall, Ligandrol is a safe and effective way to boost muscle mass and strength. If you are looking for a powerful SARM that can help you make amazing gains, Ligandrol is worth considering!
Legal
Disclaimer: SARMs are intended only for research purposes as it is non-approved. LGD 4033 is a highly active SARM used in weight lifting to increase the strength and hypertrophy of muscles. Several of the agonists of the androgen receptor are promising as a potential way for treating the underlying cause of cachéxia. LGD-4033 is strongly bound to the androgen receptor, similar to steroids, but has little influence on esthetics or growth hormones.
Resources
https://examine.com/supplements/ligandrol-lgd-4033/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836593/
https://www.healthline.com/health/food-nutrition/ligandrol-lgd-4033
